Informative Articles

In people and domestic animals, scarring in the skin after trauma, surgery, burns or a sports injury is an important medical problem, usually resulting in altered aesthetics, loss of function, restriction of tissue movement and/or growth and negative psychological effects.

Modern treatments are strictly empirical, troublesome and uncertain. There are no prescription medicines for the avoidance or treatment of dermal scarring. Skin wounds on early mammalian embryos heal perfectly with no scars, whereas wounds to adult mammals are prone to scarring.

In scar treatment research, specialists are exploring the cellular and molecular differences between perfect healing in embryonic wounds and scar-forming healing in adult wounds. Important differences include the inflammatory reaction, which in embryonic wounds consists of fewer numbers of less differentiated inflammatory cells. This occurrence, together with augmented levels of morphogenetic molecules involved in skin growth and morphogenesis, implies that the growth factor profile of an embryonic injury is very different from that of an adult injury.

These experiments resulted in scar-less healing in the adult subject and have lead to the identification of appropriate therapeutic targets. It has been found that effective skin care markedly improves or completely avoids scarring during adult injury healing in experimental animals. Some of these new medications have successfully passed safety and other tests, such that they have entered human medical trials with approval from the appropriate regulatory authorities. Based on auspicious results from these volunteer studies, the leading medications have now entered human patient-based trials e.g. in skin graft donor sites.

Scientific Research on Scar Treatments

The hypothesis is that evolutionary pressures have been exerted on intermediate sized, widespread, dirty wounds with high tissue damage e.g. bites, bruises and contusions. Modern wounds (e.g. resulting from trauma or surgery) caused by sharp objects, are new occurrences not previously found in nature, in which the evolutionary selected wound healing reactions are somewhat useless. It has been shown that both repair with scarring and regeneration can occur within the same animal, including man, and of course within the same tissue, thereby suggesting that they share similar mechanisms and regulators.

Consequently, by slightly altering the proportion of growth factors present in adult wound healing, we can induce adult wounds to heal perfectly with no scars, with accelerated healing and with no negative consequences, e.g. on wound strength or wound infection rates. This implies that scarring may no longer be an inevitable consequence of modem injury or surgery, and that a fully new pharmaceutical approach to the avoidance of human scarring is now possible. Not only skin suffers from scarring; they can appear in many other tissues as well.

Thus scar-improving drugs could have widespread benefits and prevent complications in several tissues, e.g. the prevention of blindness after scarring due to eye damage, support of neuronal reconnections in the peripheral and central nervous system by the avoidance of glial scarring, restitution of normal gut and reproductive function by preventing strictures and adhesions after damage to the gastrointestinal or reproductive systems, and the restoration of locomotor function by preventing scarring in tendons and ligaments.

Scars caused by wounds, burns or surgeries can now be easily faded. Dissolve scars with an exclusive formulation that rejuvenates injured cells.